منابع مشابه
Emerging trends for radioimmunotherapy in solid tumors.
Due to its ability to target both known and occult lesions, radioimmunotherapy (RIT) is an attractive therapeutic modality for solid tumors. Poor tumor uptake and undesirable pharmacokinetics, however, have precluded the administration of radioimmunoconjugates at therapeutically relevant doses thereby limiting the clinical utility of RIT. In solid tumors, efficacy of RIT is further compromised ...
متن کاملPharmacokinetic analysis of an improved humanized monoclonal antibody designed for radioimmunotherapy ( RIT )
Many adenocarcinomas of the digestive tract develop from premalignant lesions, induced by bacteria, chemicals or nutritional components. Early detection, differential analysis and treatment of these cancer precursors is very often crucial for survival. Conventional human hybridoma technology offers the unique possibility to generate new fully human monoclonal antibodies for diagnosis and therap...
متن کاملIntracavitary radioimmunotherapy to treat solid tumors.
Radioimmunotherapy (RIT) potentially is an attractive treatment for radiosensitive early-stage solid tumors and as an adjuvant to cytoreductive surgery. Topical administration of RIT may improve the efficacy because higher local concentrations are achieved. We reviewed the results of locally applied radiolabeled monoclonal antibodies for the treatment of solid tumors. Intracavitary RIT in patie...
متن کاملbrain tumors in elderly
brain tumors in elderly are increasing as the number of people, who comprise the older population, does.about half of the patients with brain tumors appear to be over 60 years of age.in this review article, glioblastoma multiform, as the most common malignant tumor of the central nervous system in elderly is discussed in details of definition, prognosis, diagnosis, treatment and differential di...
متن کاملChemotherapy Synergizes with Radioimmunotherapy Targeting La Autoantigen in Tumors
BACKGROUND To date, inefficient delivery of therapeutic doses of radionuclides to solid tumors limits the clinical utility of radioimmunotherapy. We aim to test the therapeutic utility of Yttrium-90 ((90)Y)-radio-conjugates of a monoclonal antibody, which we showed previously to bind specifically to the abundant intracellular La ribonucleoprotein revealed in dead tumor cells after DNA-damaging ...
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ژورنال
عنوان ژورنال: Nuclear Medicine and Molecular Imaging
سال: 2019
ISSN: 1869-3474,1869-3482
DOI: 10.1007/s13139-019-00618-6